Selectively Targeting Metabolism in Mitochondria In Cancer Cells | Cancer Biology
Prolongation of survival induced by four doses of CPI-613 (25 mg/kg),... | Download Scientific Diagram
A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process | SpringerLink
Cancers | Free Full-Text | The Metabolic Inhibitor CPI-613 Negates Treatment Enrichment of Ovarian Cancer Stem Cells
ラファエルホールディングスの適時開示・その他 | 米国株|株探(かぶたん) - 株探
Cancers | Free Full-Text | The Metabolic Inhibitor CPI-613 Negates Treatment Enrichment of Ovarian Cancer Stem Cells
A phase I study of the first-in-class antimitochondrial metabolism agent, CPI-613, in patients with advanced hematologic malignancies. - Abstract - Europe PMC
A comprehensive analysis of clinical trials in pancreatic cancer: what is coming down the pike? | Oncotarget
An integrated in vivo and in silico analysis of the metabolism disrupting effects of CPI-613 on embryo-larval zebrafish (Danio rerio) - ScienceDirect
A combination of CPI-613 and chloroquine significantly suppressed tumor... | Download Scientific Diagram
Finding Targets in Cancer's Metabolic Quirks
Devimistat – Drug Approvals International
Mitochondria in cancer metabolism, an organelle whose time has come? - Abstract - Europe PMC
Predictive targeting of mitochondrial metabolism in Acute Myeloid Leukemia patients with a lipoic acid analog | medRxiv
The Pyruvate Dehydrogenase Complex in Cancer: Implications for the Transformed State and Cancer Chemotherapy | IntechOpen
CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling | Journal of Experimental & Clinical Cancer Research | Full Text
Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial - The Lancet Oncology
Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation | Scientific Reports